Spike glycoprotein receptor-binding domain (RBD) ntawm SARS-CoV-2 mediates tus kab mob particle txoj kev khi rau angiotensin-hloov enzyme 2 (ACE2) receptor nyob rau saum npoo ntawm tib neeg lub hlwb.Yog li, Spike-ACE2 kev sib cuam tshuam yog qhov tseem ceeb rau kev txiav txim siab rau kev kis kab mob.Ib pawg phylogenetic tshiab ntawm SARS-CoV-2 (lineage B.1.1.7), uas muaj cov amino acid hloov pauv hauv Spike RBD (N501Y kev hloov).
Raws li kev tshawb fawb tshiab los ntawm Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv ntawm UK, raws li cov ntaub ntawv ntawm tag nrho genome sequencing, kev kis kab mob thiab kev ua qauv, kev sib kis ntawm cov kab mob sib txawv ntawm SARS-CoV-2 yuav luag 40-70% siab dua li lwm tus kws tshawb fawb pom tau pom. .Cov lus teb ceev ceev thiab kuaj pom yog ib qho tseem ceeb ntawm kev tiv thaiv thiab kev ntsuas ntsuas.
Cov khoom siv no yog siv rau hauv vitro qualitative detecting ORF1ab/N/S genes of novel coronavirus 2019-nCoV in respiratory specimens, and performing mutation typing on N501Y ib txhij.
Cov khoom siv tau txais txoj hauv kev ARMS, siv S gene ntawm tus kabmob tshiab (2019-nCoV) ua thaj chaw lub hom phiaj rau kev hloov pauv, tsim cov primers tshwj xeeb thiab sojntsuam rau N501Y.
| Cov khoom | Specs | Khaws cia temp | Kev piav qhia |
| Real Time PCR Kit rau NovelCoronavirus 2019-nCoV andNovel Coronavirus 2019-nCoVGene Mutation (N501Y) | 48t ua | -20 ℃ | Analytes: Tsiaj-hom N501Y,Mutant hom N501Y, ORF1ab,N gene thiab Internal tswj |
Template Compatibility
- Oropharyngeal Swabs
- Nasopharyngeal swb
- Bronchoalveolar Lavage kua dej
- Cov hnoos qeev
Cov khoom siv
- RT-PCR cov tshuaj tiv thaiv tsis haum
- RT-PCR enzyme mix
- Wild-type zoo tswj
- Mutated zoo tswj
- Kev tswj tsis zoo
N501Y Kev hloov pauv hom
